CLINICAL AND HEMATOLOGICAL ASPECTS OF PRIMARY MYELOFIBROSIS

Primary myelofibrosis (PMF) is a chronic clonal stem cell disease that causes an accumulation of marrow fibrosis and dysfunction, hypermetabolic states, and extramedullary myeloid metaplasia. The onset of the disease is often asymptomatic, which causes a late referral to a specialist, the disease being already confirmed in the fibrotic stage with a massive splenomegaly, which lowers the survival rate of patients with an established diagnosis. The insufficiency of data on clinical aspects, manifestations, risk factors, treatment and prognosis of PMF in the Republic of Moldova, served as the purpose for studying the given pathology in order to avoid the increase in morbidity, frequent relapses of the disease, the appearance of immune complications of the disease that can lead to death patients [1]