Synthesis of 1,3,5-thiadiazines from formamidinothiocarbamide

Department of Chemistry, Mahatama Fule Mahavidyalaya, Warud-444 906, Maharashtra, India Department of Chemistry, Jijamata Mahavidyalaya, Buldhana, Maharashtra, India E-mail : meshelke@rediffmail.com Manuscript received 25 May 2005, revised 12 September 2005, accepted 11 November 2005 Novel series of 2-substitutedamino-4-(2-imino-4-thiobiureto-5-yl-carbamidino)-6-substitutedimino-1,3,5 thiadiazines (3a-f) and 2-substitutedamino-4-(4-imino-6-substitutedimino-1,3,5-thiadiaz-2-yl)-6-substitutedimino- 1,3,5- thiadiazines (5a-f) has been obtained by basification of their hydrochlorides (la-O and (4a-f) respectively. The latter were synthesized by the interaction of 1-formamidino-3-thioamido-N substitutedformamidinothiocar bamides (la-O and Nsubstitutedisocyanodichloride in 1 : 1 and 1 : 2 molar ratio respectively which were prepared initially by the condensation of aryllalkylisothiocyanate and 1,3-diformamidinothiocarhamide in 1 : 1 molar ratio. The structure of all these compounds were established on the basis of elemental analysis, IR and PMR spectral data