FORMULATION AND INVITRO EVALUATION OF ECONAZOLE NITRATE TOPICAL GEL

In the present work an attempt was being made to formulate and evaluate Topical gel containing anti inflammatory drug Econazole nitrate. Carbopol 971, Guar gum and carbopol 934 were selected as polymers.The drug and excipient compatability was studied by using FTIR Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs.All the results were with in the limits , by diffusion studies it was observed that formulation F7 shown maximum drug release of 95.49% which was considered as optimized formulation. Key words: Econazole nitrate, Topical , Carbopol 971, Guar gum and carbopol 93