Synthesis of Some N-[2-(2,4-Dialkoxy-5-Alkylphenyl) Ethyl]. 2,4-Dialkoxy-5-Alkylbenzenepropanamine Hydrochlorides as Antiamoebic Agents

Department of Chemistry, University of Jammu, Jammu-180 001 Microbiology Section, Central Drug Research Institute, Lucknow-226 001 Manuscript received 8 March 1982, revised 5 November 1982, accepted la March 1983 Sixteen N-[2-(2,4-dialkoxy-5-alkylphenyl) ethyl]-2,4-dialkoxy-5-alkylbenzenepropa­namine hydrochlorides have been synthesised from 2,4-dialkoxy-5-alkylbenzenepropanoyl chlorides by condensation with 2,4-dialkoxy-5-alkylbenzeneethanamines followed by LAH reduction. These have been tested in vitro against E. histolytica for antiamoebic activity