THE ROLE OF TORCH INFECTION IN EARLY MISCARRIAGE. MORPHOLOGICAL STUDY

Background: Early miscarriage is the spontaneous loss of intrauterine pregnancy before 12 weeks of gestation. Spontaneous abortion is a frequent complication of pregnancy that represents approximately 10% of pregnancy pathologies and 80% of all abortions. The most susceptible period in pregnancy for early abortion is in the first 10 weeks of gestation when organogenesis takes place. The study of the clinical-morphological peculiarities in spontaneous abortion causes changes in the chorio-villus profile and the gestational vascular remodelling with the development of primary placental insufficiency. TORCH infections are a major source of pregnancy disruption at early gestational age. Conclusions: Placental components, particularly the syncytiotrophoblast (SYN), represent an important protective barrier in the transmission of transplacental infections. TORCH infection, during the gestation period, causes disturbances in the early development of the placenta with the involvement of the vascular component and the villous profile with a negative impact on the pregnancy resulting in miscarriage. The evaluation of the morphopathological profile during the early development period of the embryo-feto-placental complex will provide information regarding the characteristic changes induced by infections in the context of the abortive disease