Glycaemic Evaluation of Folk Recipe (Medicinal Plants) in Alloxan Induced Diabetic Rabbits

Aim/Background: The present study was planned to evaluate the antidiabetic activity of ‘Folk recipe’ a combination of traditional medicinal plants in normoglycemic and alloxan-induced diabetes rabbits. The level of antioxidant activity was determined by DPPH in relation to the total phenolic contents. Methods: Antidiabetic activity of aqueous extract of Folk Recipe (AFR) in 100-300 mg/kg, b.w. doses was determined by estimating blood glucose and serum insulin levels before and 1, 2, 4, 8, 24, 48 and 72 hour post-treatment(s) intervals in treated rabbits. Total phenolic contents and DPPH-antioxidant activity of AFR were measured in vitro. Results: AFR showed a dose dependent antidiabetic activity; maximum effect was established with 300 mg/kg, b.w. dose. The extract exerted a high significant (P<0.001) hypoglycemic effect in normal and alloxan diabetic rabbits. Extract showed a significant (P