FORMULATION AND EVALUATION OF ANTI -ACNE GEL OF TABERNAEMONTANA DIVARICATE

Acne, as a family of skin disorders is one of the most prevalent dermatologic diseases in the world. It usually affects almost everybody during the life. The use of natural remedies, particularly herbal medicine, dates back thousands of years. Over the last decade, in view of increasing resistance to existing anti-microbial agents, side effects and sometimes high cost of treatment, interest in medicinal herbs has been progressively increased. The plant Tabernaemontana divaricata, is an evergreen shrub or small tree native to South Asia, Southeast Asia and China. The root is used to treat hypertension, headaches, scabies, and toothaches. The roots, leaves, and flowers are all used to treat snake and scorpion poisoning. Non-medical uses include using the wood as incense and perfume or using the pulp around the seed to make red dyes. This study aims to evaluate the gel of Tabernaemontana divaricate for its antimicrobial effect against P.acne. the leaves of this plant is collected & subjected to successive extraction, extractive value & Phytochemical tests . The gel was then prepared and analyzed for various parameters including antimicrobial effect. The antimicrobial effect of extract was evaluated by well diffusion method. The results showed that yields were found to be 8.24g for aqueous extract. The phytochemicals like terpenoids, phenols, Carbohydrates, Flavonoids were found to be present. The Colour of formed gel was Brown with good homogenesity & consistency. The pH of gel was 6.8. The Spreadibility was 31(gm.cm /sec). The Extrudability was 548 and Viscosity (CPS) was observed as 36.6. The zone of inhibition for 100 mg/ml of extract was found to be 12±0.2mm against P. acne Keywords: Tabernaemontana divaricate, P.acne, gel, Anti- microbial activit