COMPARATIVE STUDY OF NIFEDIPINE ISOXSUPRINE IN THE TREATMENT OF PRETERM LABOUR

Preterm labour complicates 5-10% of pregnancy and leading cause of neonatl mortality and morbidity worldwide. It is major health problem in terms of loss of life and long term disability. Tocolytics are pharmacological agents, they relax the uterine myometrium and inhibit contractions leading to abolition of preterm labour and is currently the principal preterm birth preventive measure. Study involved 120 patients with the diagnosis of preterm labour with gestational age of 28-36 weeks. They were divided in two groups treated with Nifedipine and I isoxuprine. Patients were follow up till delivery and outcome parameters measured. The prolongation of pregnancy was 31-68 days in Nifedipine and 27-54 days in Isoxuprine group which statistically significant. Success rate with Nifedipine was found to be 96% as compared to Isoxsuprine which was 75%