HOST- GUEST INTERACTION OF 3-(4-CHLOROPHENYL)-1-CYCLOPROPYL-2-(2-FLUOROPHENYL)-5-(4-FLUOROPHENYL) PENTANE-1, 5-DIONE: Β-CYCLODEXTRIN INCLUSION COMPLEX

The inclusion complex of 3-(4-chlorophenyl)-1-cyclopropyl-2-(2-fluorophenyl)-5-(4-fluorophenyl) pentane-1, 5-dione (CFPD) and β-Cyclodextrin (β-CD) has been investigated using UV and fluorescence spectroscopic techniques. The binding constant and 1:1 stoichiometry of the inclusion complex were determined using Benesi- Hildebrand plots. 1:1 stoichiometry for CFPD: β-CD has been confirmed by Job’s plot. The thermodynamic parameter (ΔG) of inclusion process was determined. The formation of the inclusion complex between CFPD and β-CD, was further confirmed by molecular docking studies are in good relationship with the results obtained through experimental methods