LIPOSOMAL GEL FOR TRANSDERMAL APPLICATION FOR THE TREATMENT OF TOPICAL INFECTIONS

Abstract Liposomes as artificial colloidal vesicular structure having hydrophilic core in a lipid bilayer membrane became one of the most tremendously explored drug delivery system. These spherical vesicles consist of amphiphilic molecule like cholesterol, sterols and can be used to deliver both hydrophilic drugs as well as lipophilic drug. These vesicles are differentiated on the basis of size, composition, method of preparation and application. Liposomes are biodegradable, non-immunogenic, biocompatible, provide targeted and prolonged release, change pharmacokinetic and pharmacodynamics attribute of drug, they find wide clinical application as diagnostic, antimicrobial, anticancer, vaccine adjuvant and cosmetics. Topical liposome formulations could be more effective and less toxic than conventional formulations. The liposome gel formulations could perform therapeutically better effects than the conventional formulations, as prolonged and controlled release topical dosage forms, may lead to improved efficiency and better patient compliance. Keywords: Liposomes, Topical, Amphiphilic, Non-immunogenic, Biocompatibl