PRDX6: A Target Enabling Package

Peroxiredoxin-6 (PRDX6) is involved in modulating oxidative stress and is expressed in numerous tissues, including brain. PRDX family members are thiol-dependent peroxidases which catalyse the reduction of hydrogen peroxide, peroxynitrite and alkyl hydroperoxides. Elevated levels of reactive oxygen species (ROS) are commonly observed in Alzheimer's disease (AD), and many other neurodegenerative diseases, and may contribute to neuronal damage initiating apoptotic processes, as noted in recent reviews. Consequently, PRDX6 may affect signalling pathways involved in neuroprotection and cell death by modulating oxidative stress. The aim of this project is to produce TEP reagents to help further understand the biology of PRDX6 in Alzheimer’s disease.Future versions of this TEP will contain experimental data on the PRDX6 TEP