Studies on Heterocyclic Compounds. Part-V : Synthesis and Antimicrobial Activities of N-Bridged Thiazole and Imidazole Derivatives

Department of Chemistry, Sambalpar University, Burla, Sambalpar-768 017 Manuscript received 28 October 1981, revised 7 June 1982, accepted 12 August 1982 Several benzoxazolo[3,2-b]thiazolium, benzothiazolo[3,2-b]thiazolium and pyridino[2,1-b]thiazolium perchlorate salts, thiazolo[3,2-a]pyrimidine and several of their higher homologues as hydrobromides (IV) and free bases, were synthesised by reacting the respective mercapto compounds with α-bromoketones. The free bases as well as the hydrobromides of 1,3,4-thiadiszolo[3,2-b]imidazoles (VI) and 1,3,4- thiadiazolo[3,2-b]imidazoles (VII) were synthesised by the reaction of aminoazoles with the same bromoketones. Besides these, the synthesis of a few reduced N-bridged thiazole compounds (V) prepared by reacting the mercapto compounds with dihalo­alkanes has been described. The structures of these compounds have been confirmed from spectral and analytical data and their bactericidal and fungicidal potencies have been evaluated