Synthesis and biological evaluation of some 2-amino-5-nitrothiazole derivatives of azetidine

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University (A Central University), Sagar-470 003, Madhya Pradesh, India E-mail : pushkalsamadhiya@rediffmail.com Manuscript received O1 August 2011, revised 29 February 2012, accepted 17 April 2012 A series of N-[2-(2-amino-5-nitrothiazolyl)ethyl]-4-(substituted phenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) have been synthesized from 2-amino-5-nitrothiazole as a starting material in four steps. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the synthesized compounds 4(a-j) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and antitubercular activity screened against M. tuberculosis