Pharmacotherapy efficacy and safety criteria based on spectral shifts in elder patients with arterial hypertension and coronary artery disease

Shtanko V. A., Tofan N. V., Khyzhnyak O. V., Yablonska V. B., Novikov S. A. Pharmacotherapy efficacy and safety criteria based on spectral shifts in elder patients with arterial hypertension and coronary artery disease. Journal of Education, Health and Sport. 2017;7(11):325-333. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1158692 http://ojs.ukw.edu.pl/index.php/johs/article/view/5219 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 06.11.2017. Revised: 20.11.2017. Accepted: 30.11.2017. PHARMACOTHERAPY EFFICACY AND SAFETY CRITERIA BASED ON SPECTRAL SHIFTS IN ELDER PATIENTS WITH ARTERIAL HYPERTENSION AND CORONARY ARTERY DISEASE V. A. Shtanko, N. V. Tofan, O. V. Khyzhnyak, V. B. Yablonska, S. A. Novikov Odessa National Medical University Internal medicine department №2 Abstract The article is dedicated to development of homeostatic criteria of efficacy and safety of drugs combinations “lisinopril, bisoprolol, indapamide, isosorbide dinitrate, acetylsalicylic acid”. These criteria are based on study of homeostatic shifts and their association with clinical and laboratory parameters on elder patients with arterial hypertension (AH) II, III stage combined with coronary artery disease (CAD). Complex clinical, biochemical, biophysical and instrumental investigation was performed in 67 patients with AH II, III stage combined with CAD. On the grounds of developed criteria was established that for patients with AH II and CAD is not recommended combination “lisinopril, acetylsalicylic acid” and for those ones with AH III and CAD prohibited combinations “lisinopril, bisoprolol, acetylsalicylic acid” and “lisinopril, bisoprolol, indapamide, isosorbide dinitrate, acetylsalicylic acid” in order to prevent development of drug induced renal dysfunction. It was also determined safety of combinations “lisinopril, bisoprolol, acetylsalicylic acid”; “lisinopril, bisoprolol, indapamide, acetylsalicylic acid” for patients with AH II and CAD and “lisinopril, bisoprolol, indapamide, acetylsalicylic acid” for those ones with AH III and CAD. Key words: pharmacotherapy, efficacy, safety, arterial hypertension, coronary artery disease, laser correlation spectroscopy