Сondition of indicators of antimicrobial resistance in patients with allergic dermatoses complicated by staphylococcal infection, depending on the severity of the diseases

The aim of the work: To determine and analyse the results of indicators of antimicrobial immunity in patients with an uncomfortable and aggravated course of allergic dermatoses using auto-serums and auto-strains of Staphylococcus aureus obtained from patients with atopic dermatitis (AD) and true eczema (ТE). Methods of research: In the study, 107 patients were examined for AD and TE who were hospitalized in the Department of Dermatology of the SЕ “Institute of Dermatology on Venereology of the National Academy of Medical Sciences of Ukraine” in 2016-2019, which included an analysis of complaints and medical history data, an assessment of the severity of the disease according to the SCORAD scale and EASI, conducting general clinical, bacteriological and immunological studies. Examination of patients was carried out during an exacerbation of the disease. Results: As a result of the studies, it was found that changes in immunological reactivity in patients with AD were more pronounced than in patients with TE, which was manifested by significant inhibition of almost all indicators of the functional activity of blood leukocytes (both indicators of the phagocytic reaction, and spontaneous and induced HCT test) from moderate to severe, this is especially noticeable in the group of patients with severe course of AD. It was shown that in patients with AD and TE in the acute stage, the formation of a secondary immunodeficiency state is observed, which is manifested by a decrease in the leukocyte phagocytic activity, which may be an indication for inclusion in the complex treatment of immunocorrective therap