Sexual dimorphism in relationships between of plasma bilirubin and some neuro-endocrine parameters

BOMBUSHKAR, Igor, ANCHEV, Anatoliy, ŻUKOW, Xawery & POPOVYCH, Igor. Sexual dimorphism in relationships between of plasma bilirubin and some neuro-endocrine parameters. Journal of Education, Health and Sport. 2022;12(11):381-389. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.11.051 https://apcz.umk.pl/JEHS/article/view/40383 https://zenodo.org/record/7431779 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.10.2022. Revised: 20.10.2022. Accepted: 28.11.2022. SEXUAL DIMORPHISM IN RELATIONSHIPS BETWEEN OF PLASMA BILIRUBIN AND SOME NEURO-ENDOCRINE PARAMETERS Igor S. Bombushkar1,2, Anatoliy S. Anchev2, Xawery Żukow3, Igor L. Popovych4 1Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine https://orcid.org/0000-0003-4260-0736 bombuchkar@gmail.com 2Donets’kian National Medical University, Kropyvnyts’kyi, Ukraine https://orcid.org/0000-0002-5051-1664 doctorjiraha@gmail.com 3Medical University of Bialystok, Bialystok, Poland https://orcid.org/0000-0001-5028-7829 xaweryzukow@gmail.com 4OO Bohomolets’ Institute of Physiology of NAS of Ukraine, Kyїv, Ukraine https://orcid.org/0000-0002-5664-5591 i.popovych@biph.kiev.ua Summary Background. Earlier we found that plasma uric acid, urea and creatinine causes modulating effects on neuro-endocrine parameters, as well as anxiety, but these effects are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma bilirubin level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of bilirubin and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma bilirubin upregulates the variability of β- and α-rhythms as well as PSD of β-rhythm in T4 and Fp2 loci, but downregulates the variability of θ-rhythm, PSD of β-rhythm in P4 and δ-rhythm in T6 loci as well as the trait anxiety. The measure of determination is 42,6% In postmenopausal women, bilirubin downregulates the PSD of β-rhythm in T6 locus, but upregulates the Testosterone plasma level, vagal tone as well as PSD of ULF and VLF bands HRV. The degree of determination of neuro-endocrine parameters is 59,2%. In women of reproductive age bilirubin upregulates the PSD of β-rhythm in T4 locus while downregulates the amplitude of θ- and β-rhythms, PSD of β-rhythm in 5 loci, of α-rhythm in 5 other loci as well as the Entropy of EEG in T5, P4 and C4 loci. The degree of determination of EEGs parameters is 97,8%. Conclusion. Plasma bilirubin has a modulating effect on psycho-neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of Ah receptors in neurons. Keywords: plasma bilirubin, cortisol, testosterone, aldosterone, triiodothyronine, calcitonin, ongoing EEG, HRV, anxiety, men, women