DEVELOPMENT AND CHARACTERIZATION OF MICROPARTICLES CONTAINING HERBAL PLANT EXTRACT FOR TREATMENT OF DIABETES

ABSTRACT Diabetes is the disease which is mainly associated with increased dosing frequency which is a major drawback, to overcome by this we have chosen novel carrier to modify the drug release mechanism from the dosage form. Incidence of diabetes mellitus increasing day by day. Synthetic drugs which are used for the treatment of diabetes have many side effects and frequency of dosing is more. To overcome such problems novel carrier system has been chose. Herbal extracts have been widely accepted as the potential medicines with less side effects as compared to synthetic drug molecules. Biodegradable polymers are having wide use for the preparation of vesicular system to control the drug release pattern of drugs. Extraction of crude drug (Aegle marmelos) done with successive solvent extraction method by using different solvents like Petroleum ether, ethyl acetate, chloroform, methanol, and ethanol. In phytochemical screening we found different constituents, which decreases blood glucose level. Polymeric microparticles formulated with hot melt method and emulsification method. After characterization the microparticles which are made from hot melt method shows good results of drug release and entrapment efficiency. In the current research work micoparticles has been developed of chitosan employed to enhance the drug release. Polymeric micopartcles were characterized and evaluated for antidiabetic activity. Aegle marmelos decrease the blood glucose level in albino rats. KEYWORDS: Microparticles, Aegle marmelos, Hot Melt method, Double Emulsification, Diabetes Mellitus