EVALUATION OF ANTIPYRETIC ACTIVITY OF ZIZYPHUS JUJUBA LAM. LEAVES ON ALBINO RATS

Objective: The objective of the study was to evaluate antipyretic activity of crude methanol extract of Zizyphus jujuba leaves. Z.jujuba commonly called, Red date or Chinese date or Bera (Pushto), belonging to family Rhamnaceae, is used primarily for its fruits. Jujube, a delicious fruit, is an effective herbal remedy improving stamina and muscular strength and aids weight gain, strengthens liver function and increases immune system resistance. Methodology: The anti-pyretic activity of methanolic extract of Zizyphus jujuba Lam leaves was evaluated to Brewer’s yeast induced pyrexia in rats with respect to control group. Results: In the first hour, the antipyretic effect of methanol extract of Zizyphus jujuba (200 and 400 mg/kg) was significant (p<0.05, and p <0.01 respectively). The results suggests that Zizyphus jujuba at a dose of 200mg/kg caused a highly significant reduction at third hour (p<0.001). However, the effect increases significantly at the dose of 400 mg/kg having (p