A CROSS-SECTIONAL RESEARCH ON ASSOCIATION OF MEDICAL SYMPTOMS AND SIGNS WITH HISTOPATHOLOGICAL DIAGNOSIS AND HYSTERECTOMY SAMPLES

Objective: The study was conducted to find out the medical symptoms and association between hysterectomy sample and its histopathological diagnosis. Methods: The design of the study was cross-sectional and it was carried out at Obstetrics department of Services Hospital, Lahore (March, 2016 to April, 2017). The sample was composed of the gynecology cases who were undertaking hysterectomy. Rest of the hysterectomy cases were excluded from the study. A pre-set form containing the patients’ clinical results and socioeconomic factors was filled for each case. Biopsy samples were sent for evaluation at histopathology laboratory and the results were analyzed with the surgery symptoms. Results: The sample was comprised of 313 female patients who underwent major operations. Most of the hysterectomies were abdominal (53.9%) and the mean value for the age of the sample under discussion was calculated to be 44.3 ± 5.3 years. The subjects were multipara women with no case below para 5. Most of the patients reported with the symptoms of uterus bleeding (59.8%) followed by abdominal pain (21.9%) and mass build up in lower part of the stomach (8.3%). The most prevalent symptoms for hysterectomy procedure included abnormal bleeding (339.6%), fibroids (29.6%) and adenomyosis (breaking up of uterus inner wall) in 8.9% patients. The final diagnosis by the histopathologic unit confirmed the presence of the abnormalities which require hysterectomy. Histopathology findings were endometrial hyperplasia, adn­exal masses, endometriosis and associated infectious diseases in pelvic region. After the histopathology evaluation, the results were found a little different from what was concluded during medical evaluation before histopathology. The values for fibroid, uterine bleeding and adenomyosis before and after histopathology were (29.6% & 32.6%), (39.6% & 16.6%) and (8.9% & 23.7%) respectively. Conclusion: It was observed that the histopathology findings are well connected with the initial clinical investigations. The hysterectomy procedure was necessary after the laboratory evaluation by histopathology unit due to uterus tumors (fibroids), abnormalities, endometriosis, endometrial hyperplasia and associated pelvic disease. Keywords: Hysterectomy, Endometriosis, Adenomyosis, Histopathology, Adnexal Masses, Multipara