The Effect of Basil Leaf (Oscimum sanctum) to the Thrombocytes Number on Mice

Basil (Oscimum sanctum) is herbal that was spread widely in Indonesia. Basil contains abundant of substances. One of the functions on basil was anti-thrombocytes effect. This effect is associated with platelet function as a mechanical plug in the vascular injury during the normal homeostatic response. The disruption in thrombocytes function leads to disturb the blood clotting process. Therefore, The aims of the research were to prove the impact of basil on the number of thrombocytes. This research used mice that divided into 3 groups, as a group I dose 250 mg/day (basil leaf infusion), group II dose 500 mg/day and the control group. We used clopidogrel as a positive control to determine the effectiveness of anti platelet effect. Data were analysed by ANOVA showed that the existence of anti-thrombocyte effect in the basil dose 500 mg/day was significantly different. This result proved that basil has anti-thrombocytes effect by decreasing thrombocytes number