TO DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY

In-situ Gel for ocular drug delivery is prepares by using mucoadhesive polymers to increase ocular residence time and minimize precorneal drugs loss of given formulation. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition like Environmental PH, temperature, & ionic strength. In response to environmental changes, installed liquid in-situ rapidly undergoes gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. KEYWORDS- In-situ Gelling System, Ketorolac Tromethamine, Sodium Alginate, HPMC K4M, Benzalkonium Chloride