ESTIMATION OF SULPHID MINERAL WATER INFLUENCE AT ITS EXTERNAL APPLICATION ON THE FUNCTIONAL STATE OF THE CENTRAL AND AUTONOMIC NERVOUS SYSTEM IN THE EXPERIMENT

Fuchco A. L. ESTIMATION OF SULPHID MINERAL WATER INFLUENCE AT ITS EXTERNAL APPLICATION ON THE FUNCTIONAL STATE OF THE CENTRAL AND AUTONOMIC NERVOUS SYSTEM IN THE EXPERIMENT. Вода: гігієна та екологія / Water: hygiene and ecology / 2018;1-4(6):46-50. ISBN 978-617-696-121-5. DOI http://dx.doi.org/10.5281/zenodo.2567484 http://www.watergigeco.com.ua ESTIMATION OF SULPHID MINERAL WATER INFLUENCE AT ITS EXTERNAL APPLICATION ON THE FUNCTIONAL STATE OF THE CENTRAL AND AUTONOMIC NERVOUS SYSTEM IN THE EXPERIMENT A. L. Fuchco State institution of higher education «Uzhgorod National University», Uzhgorod The mechanisms of hydrogen sulfide influence, its role in the metabolism of mammals, at the cellular, organ and systemic levels are focused extensively, but some issues require further study. In this aspect, the study of hydrogen sulfide effect on the nervous system of a healthy body is important today. The objective. Investigate the effect of sulfide (77 mg / l) low-mineralized water (MW) when applied externally to the functional activity of the central (CNS) and autonomic (ANS) nervous system of healthy white rats. The animals got a course of 6 external procedures for 20 minutes every other day. The study of CNS and the emotional state was carried out in the «open field» mount The rats’ motor activity decreased by 80 %, and their research behavior decreased by 50 % under the influence of sulfide MW. The stimulation of the rats’ emotional activity was established: the number of grooming acts and its duration increased by 60 % and by 137 % The number of acts of urination decreased by 80 %, which indicates a decrease in the emotional stress of animals. At the same time, the animals were not slowed down, they moved quietly along the mount. The rats did not look alarmed; and a significant part of the experience they were engaged in grooming, which indicates an excellent emotional state. The studies carried out show that at transdermal application, sulfide MW does not cause toxic effects, has a regulating one on the activity of the nervous system, namely it has a moderate sedative effect on the functional activity of the CNS, reduces emotional stress and improves the emotional state of animals. Key words: hydrogen sulfide, mineral water, central and autonomic nervous system, white rats