Antidermatophytic studies of some 2-chloro-quinoline analogues

Chemistry Research Laboratory, Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India E-mail : nawaz_f@yahoo.co.in, mohanaroopan.s@vit.ac.in In this study, a series of 2-chloro-quinoline-3-carbaldehydes (1a-g) and (2-chloro-quinolin-3-yl)-methanols (2ag) were tested for their antidermatophytic studies against four species of dermatophytes : T. rubrum, E. floccosum, T. mentagrophytes and M. gypseum by well diffusion method. Compounds 1c, 1e and 2a showed good activity where as compound 2d exhibit moderate activity when compared with that of standard fluconazole