Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis

Kuchma, Igor L., Korda, Mykhaylo M., Klishch, Mykola I., Popovych, Dariya V., Żukow, Xawery, Popovych, Igor L. Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis. Journal of Education, Health and Sport. 2022;12(5):362-385. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.05.029 https://apcz.umk.pl/JEHS/article/view/39817 https://zenodo.org/record/7052152 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.05.2022. Revised: 21.05.2022. Accepted: 31.05.2022. ROLE OF AUTONOMOUS AND ENDOCRINE FACTORS IN IMMUNOTROPIC EFFECTS OF NITROGENOUS METABOLITES IN PATIENTS WITH CHRONIC PYELONEPHRITIS Igor L. Kuchma1, Mykhaylo M. Korda2, Mykola I. Klishch2, Dariya V. Popovych2, Xawery Żukow3, Igor L. Popovych1,4 1Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine igorkuchma@ukr.net 2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine cordamm@yahoo.com klishch@tdmu.edu.ua darakoz@tdmu.edu.ua 3Medical University of Bialystok, Bialystok, Poland xaweryzukow@gmail.com 4Bohomolets’ OO Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine i.popovych@biph.kiev.ua Abstract Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as patients with dysfunction of neuroendocrine-immune complex, encephalopatia and chronic pyelonephritis. The purpose of this study is clarification of the role of neuro-endocrine factors in their immunotropic activity in patients with chronic pyelonephritis. Materials and Methods. The object of observation were 17 men (aged 24-70 years) with chronic pyelonephritis in remission. The plasma levels and urinary excretion of nitrogenous metabolites as well as parameters of immunity and its neuro-endocrine regulation twice (on admission and after balneotherapy at the Truskavets’ Spa) was performed. Results. Judging by the multiple correlation coefficient, uricosuria exhibits maximal neuro-endocrine activity (R=0,780), followed by bilirubinemia (R=0,742), creatinineuria (R=0,692), uricemia (R=0,636), creatinineemia (R=0,632), urea excretion (R=0,536), instead urea plasma correlate with neuro-endocrine parameters insignificantly (R=0,360). Nitrogenous metabolites together determine the state of neuro-endocrine regulation by 94,2%, which, in turn, determine the state of immunity by 99,9%. Conclusion. Nitrogenous metabolites carry out immunomodulation in different ways: directly through aryl hydrocarbon (bilirubin), toll-like and adenosine (uric acid) receptors of immunocytes; through modulation of the activity of neurons of the autonomous nervous system and endocrinocytes with subsequent neuro-endocrine immunomodulation; and also, apparently, due to an off-receptor effect on neurons, endocrinocytes and immunocytes (urea and creatinine). Keywords: bilirubin, uric acid, urea, creatinine, immunity, HRV, adaptation hormones, relationships, chronic pyelonephritis