Induction effect combination of Nigella sativa extract and bovine bone graft to the area of woven bone on the preservation socket post-tooth extraction

Background: Tooth extraction is a common dentistry procedure followed by alveolar bone resorption. Trauma that occurs in tooth extraction will induce exaggerating inflammatory process, leads to increased alveolar bone resorption. Bone resorption can be minimized by administering a combination of Nigella sativa extract and bovine bone graft. The combination material is expected to increase the woven bone area formation and speed up the alveolar bone remodeling process. Purpose: To determine the effect of induction of a combination of Nigella sativa extract and bovine bone graft in the formation of the woven bone area on tooth extraction sockets. Methods: The lower left incisor of Cavia cobaya was extracted and the socket was given materials according to their group, namely, control group, bovine bone graft group, Nigella sativa extract group, and a combination of Nigella sativa extract and bovine bone graft group. Cavia cobaya was sacrificed on day 7 and day 14. Histological observation was carried out with hematoxylin-eosin staining. Results: The highest formation of the woven bone area resulted from the group that was treated with a combination of Nigella sativa extract and bovine bone graft, both on day 7 and day 14. Conclusion: The combination of Nigella sativa extract and bovine bone graft is able to increase the formation of woven bone area in the tooth extraction socket