Synthesis, spectral and antimicrobial activity of CoII, NiII, CuII and ZnII metal complexes of 1-(1-(furan-2-yl)ethylidene)-2-( (3-methyl-2H-benzo[ e] [1 ,2,4]oxadiazin-2-yl) (phenyl)methylene )hydrazine

Department of Chemistry, Institute of Basic Sciences, Dr. B. R. Ambedkar University, Khandari Campus, Agra-282 002, Uttar Pradesh, India E-mail : dev _ ku mar26@ indiatimes. com Manuscript received 29 December 2010, revised 20 May 2011, accepted 07 September 2011 CoII, NiII , CuII and ZnII complexes of l-(1-(furan-2-yl)ethylidene)-2-((3-methyi-2H-benzo{e)(l,2,4]oxadiazin-2-yl)(phenyl)mcthylene)hydrazine have been synthesized and characterized by TLC, elemental analyses, IR, 1H NMR, magnetic moment values, electronic spectral and thermal studies. All the synthesized compounds, viz. (3-methyi-2Hbenzo [ e 1 [1 ,2, 4]oxadiazin-2-yl)-phenyl-methanone (2), 3-phenyl-3-(3-methyl-2H-benzo{ e] {1 ,2,4]oxadiazin-2-yl)hydrazone (3), 1-(1-(furan-2-yl)ethy lidene)-2-( (3-methyi-2H-benzo[e] 1 [1 ,2,4]oxadiazin-2-yl) (phenyl)methylene)hydrazine ( 4) and their metal complexes (Sa-d) were screened for antimicrobial activities in vitro against gram + ve bacteria (Staphylococcus aureus) and gram -ve bacteria (Escherichia coli) and two fungi Aspergillus niger and Aspergillus flavus. Compound (2) exhibited significant antimicrobial activity which increased in its hydrazone (3). The activity further increased in the form of its derivative (4). However, metal complexes exhibited maximum activity against both bacteria and fungi