Anti-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats

ABSTRACT Background: Recently the role of apelin in inflammation has been known. However, the effect of exercise training-induced cytokine apelin in diabetes status hasn’t been investigated. The purpose of this study was to determine the anti-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats. Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-α and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation was used for analyzing data. P