Heamatological Response in Testosterone Propionate Induced Prostatitis Co-Treated with Aqueous Leaf and Seed Extracts of Artocapus Heterophyllus

This study seeks to examine the effects of aqueous extracts of Artocarpus heterophyllus leaves and seeds on haematological profile of prostatic male wistar rats induced using testosterone propionate (TP). One hundred male wistar rats (100-125g) grouped into 10 of 10 rats each were obtained from the Department of Pharmacology, University of Port Harcourt Animal House. The various groups were fed and administered with various concentrations (100mg/kg, 200mg/kg, 300mg/kg and 200mg/kg combined extract) of the leaves and seeds extracts of A.heterophyllus. The haematological profile was done on the male Wistar rats on day 21, 42 and 63 of the experiment using standard laboratory methods. Results obtained revealed that the leaves and seeds extracts were shown to have a stabilizing and ameliorative effect on the haematological parameters With PCV (%) range 13.20±0.21 in group 2 at day 42 with maximum values 39.67±0.20 seen in group 5 day 42. HB(g/dl) 5.00±0.15 (group 2 day 63) to 13.23±0.39 (group 5 day 42), RBC(X1012/l) count 1.45±0.14 (group 2 day 42) to 5.93±0.15 (group 5 day 42), WBC (X109/l) 4.07±0.20 (group 5 day 42) to 37.80±0.34 (group 2 day 42), Platelet(X109/l) 201.33±0.09 (group 5 day 42) to 363.00±0.52 (group 2 day 21), Neutrophils 20.33±0.49 (group 5 day 42) to 49.35±0.34 (group 2 day 42), Lymphocytes 52.30±0.51 (group 5 day 42) to 84.24±0.17 (group 2 day 42), Eosinophils 2.10±0.57 (group 5 day 42) to 9.00±0.53 (group 2 day 42) , Monocytes 5.33±0.32 (group 5 day 42) to 12.67±0.53 (group 2 day 42). These values obtained were shown to be significantly different with the negative control (induced untreated) group and not significantly different from the normal and standard drug treated group revealing high ameliorative potentials especially in groups 5 (Rats induced with TP 4mg/kg and administered 200mg/kg of aqueous extract of Arthocarpus heterophyllus leaves) by day 42