Relationships between changes in entropy of the EEG and parameters of the immunity

Popadynets’ Oleksandr O.1, Gozhenko Anatoliy I.1, Badiuk Nataliya S.1, Zukow Walery2, Kovbasnyuk Marta M.3, Korolyshyn Tetyana A.3, Popovych Igor L.1,3. Relationships between changes in entropy of the EEG and parameters of the immunity. Pedagogy and Psychology of Sport. 2020;6(1):24-40. elSSN 2450-6605. DOI http://dx.doi.org/10.12775/PPS.2020.06.01.003 https://apcz.umk.pl/czasopisma/index.php/PPS/article/view/PPS.2020.06.01.003 https://zenodo.org/record/3661196 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.01.2020. Revised: 25.01.2020. Accepted: 10.02.2020. RELATIONSHIPS BETWEEN CHANGES IN ENTROPY OF THE EEG AND PARAMETERS OF THE IMMUNITY Oleksandr O. Popadynets’1, Anatoliy I. Gozhenko1, Nataliya S. Badiuk1, Walery Zukow2, Marta M. Kovbasnyuk3, Tetyana A. Korolyshyn3, Igor L. Popovych1,3 1Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine daddysbestmail@gmail.com 2Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl 3OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine i.popovych@biph.kiev.ua Abstract Background. Previously, we have shown that the entropy of the normalized parameters of the HRV and spectral power density (SPD) of loci of EEG significantly correlate with the entropy and parameters of immunity, which testifies to their modulating regulatory effects. The purpose of this study is to analyze the relationships between changes in entropy and immunity under the influence of natural adaptogens. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystitis in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). Than we evaluated immune status on a set of I and II levels recommended by the WHO. The Entropy of normalized SPD for each locus of EEG and HRV as well as Immunocytogram and Leukocytogram calculated using Shannon’s formula. Results. Preliminary analysis revealed different orientation of entropy changes in patients, so three clusters were created. Balneotherapy has a generalized negentropic effect on EEG of 2/3 patients. On the other hand, the members of the other two clusters have substantially increased EEG entropy overall, but there are significant differences with respect to individual loci. The immunotropic effects of balneotherapy are unrelated to changes in integral entropy of EEG. As a result of discriminant analysis were selected as characteristic entropy changes at only 9 loci out of 16, accompanied by changes in 10 partial parameters of immunity and integral immune index, as well as Popovych’s Leukocytogram Strain Index-2. Conclusion. Balneotherapy causes multivariate entropy changes of individual EEG loci, conditioned by a number of predictors. This is accompanied by characteristic changes in certain parameters of immunity in line with the concept of immune homunculus. Key words: EEG, HRV, Immunity, Entropy, Relationships, Balneotherapy