Microwave assisted one pot green synthesis of novel isoxazoline derivatives using N-methyl-α-chloro nitrone and their antibacterial activities

Organic Chemistry Laboratory, Sikkim Government College, Gangtok-737 I 02, Sikkim, India E-mail : bcorgchem@hotmail.com Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India Manuscript received 30 June 2011, revised 19 January 2012, accepted 27 September 2012 Microwave assisted 1,3-dipolar cycloaddition reaction of N-methyl-α-chloro nitrone with various alkynes as dipolarophile have been studied and found to afford diastereomeric novel isoxazoline derivatives with high selectivity. All the synthesized compounds have been screened for their antibacterial activity and are found to exihibit significant activity