Cognitive symptomes associated with antipsychotic course experience in residual schizophrenia

Safonov D. M. Cognitive symptomes associated with antipsychotic course experience in residual schizophrenia. Journal of Education, Health and Sport. 2021;11(06): 268-274. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.06.030 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.06.030 https://zenodo.org/record/5517992 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 21.05.2021. Revised: 03.06.2021. Accepted: 30.06.2021. COGNITIVE SYMPTOMES ASSOCIATED WITH ANTIPSYCHOTIC COURSE EXPERIENCE IN RESIDUAL SCHIZOPHRENIA D. M. Safonov Zaporizhzhya State Medical University Abstract Urgency. The cognitive symptoms of schizophrenia are recognized either as a part of a negative complex of symptomatic, where cognitive malfunction seem to be the secondary complication of emotional and motivational dysregulation; or as a separate group of schizophrenia manifestations that constitutes a massive part of a residual condition. Aim – to evaluate the cognitive functioning and analyze its violation levels in association with antipsychotic course experience in patients with residual schizophrenia. Materials and methods. A study was performed on 100 patients of Zaporozhye Regional Clinical Psychiatric Hospital who were treated as inpatients with diagnosis of recurrent schizophrenia (ICD-10:F20.5). The methods used: anamnestic psychodiagnostics and statistical. As a main psychodiagnostics tool we used “Brief Assessment of Cognition in Schizophrenia”. Results. The assessment of cognitive functions was established by direct testing in clinical setting. Education in years varied from 9 to 16, mean 11,27±2,12 in the population under study. The basic level of cognitive impairment was established: verbal memory test result was 31,6±11,6; digit sequencing test result was 13,4±5,7; token motor task test result was 40,1±18,3; verbal fluency test result was 41,2±10,7; symbol coding test result was 30,6±13,1; tower of london test result was 12,2±4,5. Some correlations were found: for chlorpromazine we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,27) results; for haloperidol we can assume more pronounced but still minor impact on token motor task (r= -0,22), verbal fluency test (r= -0,27), verbal memory test (r= -0,28) and tower of London test (r= -0,20) results; for trifluoperazine we can see minor negative impact on verbal fluency test (r= -0,26); for clozapine we can’t find any representative correlations with cognitive tests; chlorprothixene as we can assume have minor negative impact on verbal memory test (r= -0,32) result, but minor positive – on tower of London test (r= 0,21) result; for risperidone also assume minor positive impact on sequence coding test (r= 0,25), but other tests in battery show no significant correlations; for zuclopenthixol we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,31) results. Conclusion. The study on cognitive functioning and its violation levels in association with antipsychotic course experience in patients with residual schizophrenia was performed. Some perspective correlations for cognitive functions testing results and antipsychotic course experience were found token motor test and verbal fluency test results could possibly be minorly negatively influenced by chlorpromazine, haloperidol and zuclopenthixol systematic intake experience, while risperidone and chlorprotexine systematic intake experience could possibly have minor positive impact on sequence coding and tower of London tests results. There were no strong correlations found and no correlation tests with organic brain impairment factors were done yet. Key words: cognitive function; organic brain impairment; residual schizophrenia