Folic acid - influence on male fertility, spermatogenesis, sperm DNA fragmentation and subsequent growth of the embryo and fetus

TRUCHTA, Monika, AUGUSTYNOWICZ, Kinga, MARCINKOWSKA, Marta, STOLIŃSKI, Michał & ŚWIĄDER, Kinga. Folic acid - influence on male fertility, spermatogenesis, sperm DNA fragmentation and subsequent growth of the embryo and fetus. Journal of Education, Health and Sport. 2023;34(1):51-60. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.34.01.004 https://apcz.umk.pl/JEHS/article/view/43762 https://zenodo.org/record/7979693 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 27.04.2023. Revised: 10.05.2023. Accepted: 28.05.2023. Published: 28.05.2023. Folic acid- influence on male fertility, spermatogenesis, sperm DNA fragmentation and subsequent growth of the embryo and fetus Kwas foliowy- wpływ na męską płodność, spermatogenezę, fragmentację DNA plemników i późniejszy rozwój zarodka i płodu Monika Truchta Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi ul. Pomorska 251, 92-213 Łódź ORCID 0009-0000-8177-9164 https://orcid.org/0009-0000-8177-9164 E-mail: monikatruchta@gmail.com Kinga Augustynowicz Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej – Centralny Szpital Weteranów Stefana Żeromskiego 113, 90-549 Łódź ORCID 0000-0003-4547-9599 https://orcid.org/0000-0003-4547-9599 E-mail: kingaugustynowicz@gmail.com Marta Marcinkowska Powiatowego Centrum Zdrowia w Brzezinach sp. z o.o. Marii Curie–Skłodowskiej 6, 95-060 Brzeziny ORCID 0009-0000-5318-1886 https://orcid.org/0009-0000-5318-1886 E-mail marta.marcinkowska96@gmail.com Michał Stoliński SP ZOZ Szpital Powiatowy im. Edmunda Biernackiego w Opocznie ul. Partyzantów 30, 26 – 300 Opoczno ORCID 0009-0005-5865-3789 https://orcid.org/0009-0005-5865-3789 E-mail michalstolinski1995@gmail.com Kinga Świąder Faculty of Medicine, Uniwersytet Medyczny w Łodzi Plac Gen. Józefa Hallera 1, 90-647 Łódź ORCID 0000-0003-0185-6524 https://orcid.org/0000-0003-0185-6524 E-mail: kingaswiader@icloud.com Abstract Introduction: Men's infertility is a multifactorial disorder. According to scientific literature, among men with reduced fertility, growing interest in folic acid is observed. This review describes the effect of folic acid on spermatogenesis, sperm concentration, sperm DNA fragmentation and the growth of the embryo and fetus. Material and methods: The work was based on the articles published in PubMed, medical books and websites. Results: Folic acid affects the trajectory of embryo growth in pregnancy conceived spontaneously, there is a negative correlation between the concentration of folic acid in the semen and the indicator of sperm DNA fragmentation and sperm concentration are statistically higher in folic acid supplements. Conclusions: The results suggest that the father's exposure to folic acid before conception may affect the health of his offspring, and therefore care before conception should be changed from an approach focused on a woman to a couple-based approach. Keywards: „Folic acid”, „spermatogenesis”, „male infertility”