Synthesis of Some Phenoxyacetyl Thiosemicarbazide Derivatives and Derived 1,3,4-Oxadiazoles

Department of Chemistry, Lucknow University, Lucknow and Industrial Toxicological Research Centre, Lucknow Manuscript received 5 June 1975; revised 28 July 1975; accepted 30 July 1975 Eleven 4-sec.-amyl phenoxyacetyl thiosemica:rbazides have been synthesised as possible insecticidal agents by the condensation of 4-sec.-amyl-phenoxyacetyl hydrazide with arylisothiocyanate, five of them have been cyclized by iodine to 2-(4-sec,-amyl-phenoxymethyl)-5-(substituted arylamino)-1,3,4-oxadiazoles. Some thiosemicarbazides have been screened for their anti-acetyl cholinesterase activity