Original data 1. Synthesis and Characterization Compounds 7, 9, 10, 11, 13, 14, 16, 33, 34, 36 Lab Book Page; 1H and 13C NMR; IR; HRMS Compound 10 Stability Test Lab Book Page UV-Vis Absorption Spectra of 10 and 41 in PBS UV- Vis Absorption Spectra of 10 in Buffer After 72 h Kinetics 10 h in PBS; and in AMPSO Buffer Compound 22 Lab Book Page Compounds 47, 48, 53, 55, 56 Lab Book Pages; 1H and 13C NMR; IR 2. Automated High-Content High-Throughput Screening Lab Book Pages and Data 2.1. Inhibitor Screening with OPS Reporter 2.2. Cellular Uptake of MAC Reporters 2.3. Inhibitor Screening with MAC and CTO Reporters 3. Protein Uptake 3.1. Preparation and Cellular Uptake of Streptavidin Comp...
Speed trap: Cysteamine reacts in DMSO with electrophilic double bonds to afford Michael adducts (see...
The KRASG12C protein product is an attractive, yet challenging, target for small molecule inhibition...
Cyclic oligochalcogenides (COCs) are emerging as promising systems to penetrate cells. Clearly bette...
Chalcogen-centered cascade exchange chemistry is increasingly understood to account for thiol-mediat...
Intracellular delivery is an essential challenge for drug development, as low membrane permeability...
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabl...
Thiol-mediated uptake is emerging as a powerful method to penetrate cells. Cyclic oligochalcogenides...
Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irre...
Thiol-mediated uptake is receiving increasing attention as an innovative way to penetrate cells. Tak...
Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covale...
Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covale...
ABSTRACT: Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacol...
Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological pot...
The literature on thia-Michael acceptors is vast and can be cherry-picked to show either that these ...
Since their discovery, cell-penetrating peptides (CPPs) has been developed as a powerful drug delive...
Speed trap: Cysteamine reacts in DMSO with electrophilic double bonds to afford Michael adducts (see...
The KRASG12C protein product is an attractive, yet challenging, target for small molecule inhibition...
Cyclic oligochalcogenides (COCs) are emerging as promising systems to penetrate cells. Clearly bette...
Chalcogen-centered cascade exchange chemistry is increasingly understood to account for thiol-mediat...
Intracellular delivery is an essential challenge for drug development, as low membrane permeability...
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabl...
Thiol-mediated uptake is emerging as a powerful method to penetrate cells. Cyclic oligochalcogenides...
Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irre...
Thiol-mediated uptake is receiving increasing attention as an innovative way to penetrate cells. Tak...
Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covale...
Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covale...
ABSTRACT: Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacol...
Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological pot...
The literature on thia-Michael acceptors is vast and can be cherry-picked to show either that these ...
Since their discovery, cell-penetrating peptides (CPPs) has been developed as a powerful drug delive...
Speed trap: Cysteamine reacts in DMSO with electrophilic double bonds to afford Michael adducts (see...
The KRASG12C protein product is an attractive, yet challenging, target for small molecule inhibition...
Cyclic oligochalcogenides (COCs) are emerging as promising systems to penetrate cells. Clearly bette...