Fig. 5 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)

Fig. 5. Schematic representation of the possible mechanism of antitumor activity of polyacetylenes. (AA, amino acid; Akt, protein kinase B; ASCT2, amino acid transporter alanine serine cysteine transporter 2; Bcl-2, B cell leukemia-2; CDK2, cyclin dependent kinase 2; Gln, glutamine; Glu, glutamate; HIF-1α, hypoxiainducible factor 1α; JAK, janus kinase; JNK, c-Jun N-terminal kinase; NF-κB, nuclear factor κB; PI3K, phosphatidylinositol 3-kinase; PTTG1, pituitary tumortransforming gene 1; STAT3, signal transducer and activator of transcription 3).Published as part of Xie, Qi & Wang, Changhong, 2022, Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021), pp. 1-20 in Phytochemistry (113288) 201 on page 12, DOI: 10.1016/j.phytochem.2022.113288, http://zenodo.org/record/823520