Fig. 1. The proposed carboxyl group formation of celastrol at the C-29 position and carboxyl group formation of β-amyrin at C-30 position by other cytochrome P450s. The red dashed arrows indicate one or multiple proposed step reactions, and the black solid arrow indicates a biosynthetic reaction catalysed by known CYP450 genes. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)Published as part of Zhou, Jiawei, Hu, Tianyuan, Liu, Yuan, Tu, Lichan, Song, Yadi, Lu, Yun, Zhang, Yifeng, Tong, Yuru, Zhao, Yujun, Su, Ping, Wu, Xiaoyi, Huang, Luqi & Gao, Wei, 2021, Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol, pp. 1-10 in Phytochemistry (11286...
Fig. 2. Synthesis and reactions of α-pinene. Biosynthetic pathway (orange); Synthetic starting point...
Fig. 1. The proposed biosynthetic pathway of shikonin in L. erythrorhizon. Single arrows represent o...
Cytochrome P450 monooxygenases (CYPs) are enzymes that play critical roles in the structural diversi...
Zhou, Jiawei, Hu, Tianyuan, Liu, Yuan, Tu, Lichan, Song, Yadi, Lu, Yun, Zhang, Yifeng, Tong, Yuru, Z...
Fig. 6. Molecular docking and mutagenesis assay of TwCYP712K1 from T. wilfordii. (a) Molecular docki...
Fig. 3. Phylogenetic tree of candidate P450s from T. wilfordii. The maximum-likelihood method was us...
Fig. 2. Hierarchical clustering of RNA-Seq expression data and heat map depicting the expression pro...
Fig. 4. Gas chromatography-mass spectrometry (GC-MS) analysis of the products in yeast strains harbo...
Fig. 5. The role of TwCYP712K1 in celastrol biosynthesis. (a) Network of differentially expressed CY...
Fig. 1. Phylogeny of cytochrome p450 enzymes. Phylogeny of cytochrome p450 enzymes found in the Aste...
F1000Research. Volume 4, July 01, 2015, Article number 178.Cytochrome P450 (CYP) enzymes are the pr...
International audienceBackground: Large proliferations of cytochrome P450 encoding genes resulting f...
Fig. 23. Reaction catalyzed by NDC1/demethylphylloquinone reductase. The penultimate step in the bio...
Fig. 8. The proposed biosynthetic pathway of 5DS and LL in L. japonicus. LjMAX1 catalyzes the oxidat...
Fig. 2. Proposed metabolic network of isoquinoline alkaloids in the Macleaya genus. a the solid arro...
Fig. 2. Synthesis and reactions of α-pinene. Biosynthetic pathway (orange); Synthetic starting point...
Fig. 1. The proposed biosynthetic pathway of shikonin in L. erythrorhizon. Single arrows represent o...
Cytochrome P450 monooxygenases (CYPs) are enzymes that play critical roles in the structural diversi...
Zhou, Jiawei, Hu, Tianyuan, Liu, Yuan, Tu, Lichan, Song, Yadi, Lu, Yun, Zhang, Yifeng, Tong, Yuru, Z...
Fig. 6. Molecular docking and mutagenesis assay of TwCYP712K1 from T. wilfordii. (a) Molecular docki...
Fig. 3. Phylogenetic tree of candidate P450s from T. wilfordii. The maximum-likelihood method was us...
Fig. 2. Hierarchical clustering of RNA-Seq expression data and heat map depicting the expression pro...
Fig. 4. Gas chromatography-mass spectrometry (GC-MS) analysis of the products in yeast strains harbo...
Fig. 5. The role of TwCYP712K1 in celastrol biosynthesis. (a) Network of differentially expressed CY...
Fig. 1. Phylogeny of cytochrome p450 enzymes. Phylogeny of cytochrome p450 enzymes found in the Aste...
F1000Research. Volume 4, July 01, 2015, Article number 178.Cytochrome P450 (CYP) enzymes are the pr...
International audienceBackground: Large proliferations of cytochrome P450 encoding genes resulting f...
Fig. 23. Reaction catalyzed by NDC1/demethylphylloquinone reductase. The penultimate step in the bio...
Fig. 8. The proposed biosynthetic pathway of 5DS and LL in L. japonicus. LjMAX1 catalyzes the oxidat...
Fig. 2. Proposed metabolic network of isoquinoline alkaloids in the Macleaya genus. a the solid arro...
Fig. 2. Synthesis and reactions of α-pinene. Biosynthetic pathway (orange); Synthetic starting point...
Fig. 1. The proposed biosynthetic pathway of shikonin in L. erythrorhizon. Single arrows represent o...
Cytochrome P450 monooxygenases (CYPs) are enzymes that play critical roles in the structural diversi...