The expression of a large number of genes is regulated by regulatory elements that are located far away from their promoters. Identifying which gene is the target of a specific regulatory element or is affected by a non-coding mutation is often accomplished by assigning these regions to the nearest gene in the genome. However, this heuristic ignores key features of genome organisation and gene regulation; in that the genome is partitioned into regulatory domains, which at some loci directly coincide with the span of topologically associated domains (TADs), and that genes are regulated by enhancers located throughout these regions, even across intervening genes. In this review, we examine the results from genome-wide studies using chromosome...
BACKGROUND: The number of reported examples of chromatin architecture alterations involved in the re...
AbstractRecent studies have shown that chromosomes in a range of organisms are compartmentalized in ...
The vast non-coding portion of the human genome is awash in functional elements and disease-causing ...
The expression of a large number of genes is regulated by regulatory elements that are located far a...
Enhancers regulate the expression of target genes across large genomic distances, but it is unclear ...
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m ...
The spatial organization of the genome is essential for the precise control of gene expression. Rece...
SummaryGene expression often requires interaction between promoters and distant enhancers, which occ...
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery r...
Developmental genes are highly regulated at the level of transcription and exhibit complex spatial a...
Regulation of gene expression spans different levels of complexity: from genomic sequence, transcrip...
Abstract Background Revealing the gene targets of dis...
Precise spatiotemporal gene expression during embryonic developmental is controlled by cis- regulato...
BACKGROUND: Recent data from genome-wide chromosome conformation capture analysis indicate that the ...
Genetic variation associated with disease often appears in non-coding parts of the genome. Understan...
BACKGROUND: The number of reported examples of chromatin architecture alterations involved in the re...
AbstractRecent studies have shown that chromosomes in a range of organisms are compartmentalized in ...
The vast non-coding portion of the human genome is awash in functional elements and disease-causing ...
The expression of a large number of genes is regulated by regulatory elements that are located far a...
Enhancers regulate the expression of target genes across large genomic distances, but it is unclear ...
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m ...
The spatial organization of the genome is essential for the precise control of gene expression. Rece...
SummaryGene expression often requires interaction between promoters and distant enhancers, which occ...
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery r...
Developmental genes are highly regulated at the level of transcription and exhibit complex spatial a...
Regulation of gene expression spans different levels of complexity: from genomic sequence, transcrip...
Abstract Background Revealing the gene targets of dis...
Precise spatiotemporal gene expression during embryonic developmental is controlled by cis- regulato...
BACKGROUND: Recent data from genome-wide chromosome conformation capture analysis indicate that the ...
Genetic variation associated with disease often appears in non-coding parts of the genome. Understan...
BACKGROUND: The number of reported examples of chromatin architecture alterations involved in the re...
AbstractRecent studies have shown that chromosomes in a range of organisms are compartmentalized in ...
The vast non-coding portion of the human genome is awash in functional elements and disease-causing ...