The study developed and evaluated Sorafenib Tosylate (SRT)-loaded polymeric microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as a potential inhalable carrier for NSCLC. MPs were prepared by spray-drying an oil-in-water (o/w) emulsion. The optimized MPs demonstrated excellent flowability, particle size of 2.84 ± 0.5 μm, zeta potential of −14.0 ± 1.5 mV, and 85.08 ± 5.43% entrapment efficiency. ATR-FTIR/DSC studies revealed a lack of characteristic peaks of the crystalline drug signifying good entrapment of the drug. MPs were spherical and uniform in SEM pictures. The MPs showed a biphasic release pattern up to 72h. The Anderson cascade impactor (ACI) investigation demonstrated the highest drug deposition at stage 4, wh...
Purpose The aim of this work was to optimize biodegradable polyester poly(glycerol adipate-co-ω-pent...
Sorafenib is an anticancer drug approved by the Food and Drug Administration for the treatment of he...
Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. ...
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphat...
In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib fo...
The objective of the current study was to enhance dissolution and oral bioavailability of the poorly...
The purpose of this study was to produce low-releasing spray-dried polymeric microparticles (MP) use...
<p>Sorafenib (SFB) has improved the treatment of hepatocellular carcinoma (HCC) and has fewer severe...
Funding Information: V. Känkänen and H.A. Santos acknowledge Bayer Oy (Finland) for financial suppor...
The drug-loaded nanocarriers have overcome various challenges compared with the pure chemotherapeuti...
Flash nanoprecipitation (FNP) is a recent developed method featuring fast processing and simple equi...
Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin...
To investigate the potential of sorafenib (SF) in preoperative chemotherapy for cervical cancer to r...
Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a chall...
Sorafenib, a molecular targeted multi-kinase inhibitor, has received considerable interests in recen...
Purpose The aim of this work was to optimize biodegradable polyester poly(glycerol adipate-co-ω-pent...
Sorafenib is an anticancer drug approved by the Food and Drug Administration for the treatment of he...
Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. ...
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphat...
In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib fo...
The objective of the current study was to enhance dissolution and oral bioavailability of the poorly...
The purpose of this study was to produce low-releasing spray-dried polymeric microparticles (MP) use...
<p>Sorafenib (SFB) has improved the treatment of hepatocellular carcinoma (HCC) and has fewer severe...
Funding Information: V. Känkänen and H.A. Santos acknowledge Bayer Oy (Finland) for financial suppor...
The drug-loaded nanocarriers have overcome various challenges compared with the pure chemotherapeuti...
Flash nanoprecipitation (FNP) is a recent developed method featuring fast processing and simple equi...
Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin...
To investigate the potential of sorafenib (SF) in preoperative chemotherapy for cervical cancer to r...
Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a chall...
Sorafenib, a molecular targeted multi-kinase inhibitor, has received considerable interests in recen...
Purpose The aim of this work was to optimize biodegradable polyester poly(glycerol adipate-co-ω-pent...
Sorafenib is an anticancer drug approved by the Food and Drug Administration for the treatment of he...
Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. ...