Epidemiological trends of DENV in Mexico from 2013 to 2019.

(A) The proportion of serotyped DENV cases between 2000 and 2018 in Mexico shown in reference to the total number of serotyped samples per year for all the country. Data provided by InDRE for this study is shown between the solid black lines (delimiting 2013 to 2018). Data from previous years was obtained from published sources [71]. The DENV-3 and DENV-4 serotypes together with potential co-infections (reported between 2013 and 2018) are grouped into the ‘Other’ category. (B) Monthly number of cases assigned to each DENV serotype in Mexico from 2013 to 2018. (C) Breakdown of serotype proportions in different geographic regions in Mexico between 2013 and 2019, relative to the total number of serotyped samples for each location. Plots were generated using the ggplot package (https://ggplot2.tidyverse.org/index.html) in R. Original base layer maps use as a source for geospatial base layer data public domain maps imported from the Natural Earth data project (https://cran.r-project.org/web/packages/rnaturalearth/index.html).