Additional file 1 Fig. S1 The intensity of Rhodamine 123 in the larval brain region after 0.5 hours of intravascular injection. Rhodamine123 was injected into the cardinal vein of Tg[flk1:EGFP] and Tg[flk1:EGFP]; abcb4-/- embryos at 3 dpf and imaged after 0.5 hours circulation. Data are expressed as mean ± SD. P-values were calculated using two-way ANOVA
<p>Ai-iv) One hour after pericardial injection of Evans blue into 8 d.p.f. Tg(fli1a:EGFP)<sup>y1</su...
Expression of GAL4DBD-Prdm12b constructs used in transfection experiments. a. Immunoblot showing exp...
The brain is protected from toxins by a tightly regulated network of specialized cells, including en...
Additional file 2. Differentially Expressed (DE) gene lists for Brain RNA seq between WT and abcb4 k...
Additional file 3. Gene Set Enrichment Analysis (GSEA) tables of the DE genes from the brain RNA seq
<p>A) Dye distribution and quantification experiments using rhodamine 123 (R123) were performed as d...
ATP‐binding cassette (ABC) transporter proteins include efflux pumps that confer multixenobiotic res...
The pathophysiology of most neurodegenerative diseases includes aberrant accumulation of protein agg...
The classic calcein-AM accumulation assay of multidrug resistance studies has been used in several v...
<p>(A). Schematic representation of EdU injections during the light time course with corresponding i...
<p>(A) Brightfield photographs of 26 hours old <i>Tg(BRE:mRFP)</i> transgenic embryos treated with D...
Figure S1. A–A”. To assess co-label of mpeg1:GFP and mpeg1:mCherry transgenes in retina, double tran...
The zebrafish (Danio rerio) is a very popular vertebrate model system, especially embryos represent ...
<p>(A) Diagram of 30 hours post-fertilization (hpf) zebrafish embryo showing the injection site used...
Certain ATP binding cassette (ABC) transporter proteins, such as zebrafish Abcb4, are efflux pumps a...
<p>Ai-iv) One hour after pericardial injection of Evans blue into 8 d.p.f. Tg(fli1a:EGFP)<sup>y1</su...
Expression of GAL4DBD-Prdm12b constructs used in transfection experiments. a. Immunoblot showing exp...
The brain is protected from toxins by a tightly regulated network of specialized cells, including en...
Additional file 2. Differentially Expressed (DE) gene lists for Brain RNA seq between WT and abcb4 k...
Additional file 3. Gene Set Enrichment Analysis (GSEA) tables of the DE genes from the brain RNA seq
<p>A) Dye distribution and quantification experiments using rhodamine 123 (R123) were performed as d...
ATP‐binding cassette (ABC) transporter proteins include efflux pumps that confer multixenobiotic res...
The pathophysiology of most neurodegenerative diseases includes aberrant accumulation of protein agg...
The classic calcein-AM accumulation assay of multidrug resistance studies has been used in several v...
<p>(A). Schematic representation of EdU injections during the light time course with corresponding i...
<p>(A) Brightfield photographs of 26 hours old <i>Tg(BRE:mRFP)</i> transgenic embryos treated with D...
Figure S1. A–A”. To assess co-label of mpeg1:GFP and mpeg1:mCherry transgenes in retina, double tran...
The zebrafish (Danio rerio) is a very popular vertebrate model system, especially embryos represent ...
<p>(A) Diagram of 30 hours post-fertilization (hpf) zebrafish embryo showing the injection site used...
Certain ATP binding cassette (ABC) transporter proteins, such as zebrafish Abcb4, are efflux pumps a...
<p>Ai-iv) One hour after pericardial injection of Evans blue into 8 d.p.f. Tg(fli1a:EGFP)<sup>y1</su...
Expression of GAL4DBD-Prdm12b constructs used in transfection experiments. a. Immunoblot showing exp...
The brain is protected from toxins by a tightly regulated network of specialized cells, including en...