Representation of co-medications and co-medications associated with dosage adjustments across therapeutic groups.

a Distribution of all co-medication pairs (left) and dosage-adjusted co-medication pairs (with ORs >1, right). Therapeutic groups of index drugs (vertical axis) are ordered by the proportion of co-medications associated with dosage adjustment, lowest in the bottom. b OR distribution where each point represents a dosage-adjusted co-medication pair. ORs >3 are observed for index drugs in the therapeutic groups A07, B01, B02, C09, J01, N02 and M01. c Proportion of dosage-adjusted co-medication pairs associated with discontinuations (cessation of index drug during concomitant treatment). Vertical axis and colour legend shared for a, b and c. Colour according to therapeutic group of the co-medication (see Fig 1 for legend). Only therapeutic groups represented by more than one index drug and at least five dosage-adjusted co-medication pairs are shown (47 therapeutic groups and 3,944 dosage-adjusted co-medication pairs). OR: odds ratio.