Parameter estimates for life history traits across mammalian orders.

Model parameter estimates for (A) reservoir-host background mortality (μR), (B) tolerance of immunopathology (TwR) (left y-axis: constant tolerance assumptions; right y-axis: complete tolerance assumptions), (C) magnitude of constitutive immunity (g0R), and (D) magnitude of human tolerance of virus pathology for a virus evolved in a disparate mammalian reservoir (TvS). Estimates are derived from (A) linear model predictions of maximum lifespan at the order level, (B) the scaled effect of order on a linear mixed model prediction of lifespan per body size, (C) the scaled effect of order on a linear mixed model prediction of neutrophil concentration for mass-specific BMR, and (D) the magnitude of human tolerance of virus pathology for a virus evolved in a disparate mammalian reservoir (TvS), corresponding to data presented in Fig 3E (main text). Default parameter values involved in the estimation process are summarized in Table 1 (main text), and estimated parameters and corresponding 95% confidence intervals by standard error are presented in S1 Table. See main text Methods and our open-source GitHub repository for a detailed walk-through of the parameter estimation process. Data and code used to generate all figure panels are available in our publicly available GitHub repository (github.com/brooklabteam/spillover-virulence-v1.0.0; doi: 10.5281/zenodo.8136864). (PNG)