<i>Evaluation of conjugates in</i> in vivo <i>models of P</i>. <i>aeruginosa lung infection</i>.

(A) Neutropenic animals were co-administered VSX-1 and bacteria (ATCC 27853). The CFU burden in the lung was measured at eight hours. Co-administration of 10 μg of VSX-1 resulted in a multi-log reduction in bacterial burden, with reduction to the limit of detection upon administering 200 μg of ADC. (B) Neutropenic animals were infected with P. aeruginosa (ATCC 27853) and were treated 1 hour post-infection with either vehicle or VSX-1 (200 μg). The CFU burden in the lungs was measured just before treatment (pre-treatment) and eight hours post-injection. (C) The acute lung infection model with P. aeruginosa PA14 (2x106 CFU/animal, 1x106 in each nostril), C57/Bl6, 10 animals per group (two experiments with 5 animal per group each time), intranasal inoculation, IP dosing (15 mg/kg) 4 hours post-infection.