Abstract The emergence and rapid spread of methicillin‐resistant Staphylococcus aureus (MRSA) raise a critical need for alternative therapeutic options. New antibacterial drugs and targets are required to combat MRSA‐associated infections. Based on this study, celastrol, a natural product from the roots of Tripterygium wilfordii Hook. f., effectively combats MRSA in vitro and in vivo. Multi‐omics analysis suggests that the molecular mechanism of action of celastrol may be related to Δ1‐pyrroline‐5‐carboxylate dehydrogenase (P5CDH). By comparing the properties of wild‐type and rocA‐deficient MRSA strains, it is demonstrated that P5CDH, the second enzyme of the proline catabolism pathway, is a tentative new target for antibacterial agents. Us...
textabstractThe spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-r...
Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a dreadful pathogen causing broad ...
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threatening path...
Elevated production of arachidonic acid (AA)-derived pro-inflammatory eicosanoids due to the concert...
Celastrol, a quinone methide triterpene isolated from <em>Tripterygium wilfordii</em> Ho...
Bacterial resistance is an ongoing challenge for pharmacotherapy and pharmaceutical chemistry. Staph...
International audienceBACKGROUND Celastrol is one of several bioactive compounds extracted from the ...
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat for effective treatmen...
The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. eff...
ABSTRACT Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threate...
Abstract—The emerging antibiotic resistant bacteria and their abilities for rapid evolution have pus...
SummaryInnovative strategies are needed to combat drug resistance associated with methicillin-resist...
(1) Background: Several triterpenoids were found to act synergistically with classes of antibiotic, ...
Background: PBP2a is a type of penicillin-binding proteins (PBPs) that cause resistivity in methicil...
Bacterial resistance is an ongoing challenge for pharmacotherapy and pharmaceutical chemistry. Staph...
textabstractThe spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-r...
Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a dreadful pathogen causing broad ...
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threatening path...
Elevated production of arachidonic acid (AA)-derived pro-inflammatory eicosanoids due to the concert...
Celastrol, a quinone methide triterpene isolated from <em>Tripterygium wilfordii</em> Ho...
Bacterial resistance is an ongoing challenge for pharmacotherapy and pharmaceutical chemistry. Staph...
International audienceBACKGROUND Celastrol is one of several bioactive compounds extracted from the ...
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat for effective treatmen...
The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. eff...
ABSTRACT Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threate...
Abstract—The emerging antibiotic resistant bacteria and their abilities for rapid evolution have pus...
SummaryInnovative strategies are needed to combat drug resistance associated with methicillin-resist...
(1) Background: Several triterpenoids were found to act synergistically with classes of antibiotic, ...
Background: PBP2a is a type of penicillin-binding proteins (PBPs) that cause resistivity in methicil...
Bacterial resistance is an ongoing challenge for pharmacotherapy and pharmaceutical chemistry. Staph...
textabstractThe spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-r...
Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a dreadful pathogen causing broad ...
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threatening path...