ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems, sequential changes in the composition of ESCRT-III polymers induced by the AAA-adenosine triphosphatase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-III polymers are organized and remodeled in space and time in a cellular context. Taking advantage of the relative simplicity of the ESCRT-III-dependent division system in Sulfolobus acidocaldarius, one of the closest experimentally tractable prokaryotic relatives of eukaryotes, we use super-resolution microscopy, electron microscopy, and computational modelin...
The endosomal-sorting complex required for transport (ESCRT) is evolutionarily conserved from Archae...
The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery...
BACKGROUND: ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes fr...
ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context ...
The endosomal sorting complex required for transport-III (ESCRT-III) and VPS4 catalyze a variety of ...
ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes fr...
Many cellular processes such as endosomal vesicle budding, virus budding, and cytokinesis require ex...
Multi-subunit ESCRT-III polymers together with the ATPase Vps4 have the unique ability to fission me...
Living systems propagate by undergoing rounds of cell growth and division. Cell division is at heart...
Living systems propagate by undergoing rounds of cell growth and division. Cell division is at heart...
Endosomal sorting complexes for transport-III (ESCRT-III) assemble in vivo onto membranes with negat...
The endosomal-sorting complex required for transport (ESCRT) is evolutionarily conserved from Archae...
The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery...
BACKGROUND: ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes fr...
ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context ...
The endosomal sorting complex required for transport-III (ESCRT-III) and VPS4 catalyze a variety of ...
ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes fr...
Many cellular processes such as endosomal vesicle budding, virus budding, and cytokinesis require ex...
Multi-subunit ESCRT-III polymers together with the ATPase Vps4 have the unique ability to fission me...
Living systems propagate by undergoing rounds of cell growth and division. Cell division is at heart...
Living systems propagate by undergoing rounds of cell growth and division. Cell division is at heart...
Endosomal sorting complexes for transport-III (ESCRT-III) assemble in vivo onto membranes with negat...
The endosomal-sorting complex required for transport (ESCRT) is evolutionarily conserved from Archae...
The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery...
BACKGROUND: ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes fr...