Quantification of fetal drug exposure remains challenging since sampling from the placenta or fetus during pregnancy is too invasive. Currently existing in vivo (e.g., cord blood sampling) and ex vivo (e.g., placenta perfusion) models have inherent limitations. A placenta-on-a-chip model is a promising alternative. A systematic search was performed in PubMed on 2 February 2023, and Embase on 14 March 2023. Studies were included where placenta-on-a-chip was used to investigate placental physiology, placenta in different obstetric conditions, and/or fetal exposure to maternally administered drugs. Seventeen articles were included that used comparable approaches but different microfluidic devices and/or different cultured maternal and fetal ce...
tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing ...
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays exte...
A challenge in modern drug therapy is to develop strategies for safer and more selective targeting o...
Quantification of fetal drug exposure remains challenging since sampling from the placenta or fetus ...
In this thesis we showed the implementation of complex biology in a large scale setting. The project...
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the leading cause...
ObjectiveStudying the biology of the human placenta represents a major experimental challenge. Altho...
The placenta is essential to the progression of a successful pregnancy. This specialized organ devel...
Decades ago the human placenta was thought to be an impenetrable barrier between mother and unborn c...
The placenta is essential to the progression of a successful pregnancy. This specialized organ devel...
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays exte...
With the commercialization of nanomaterials, environmental exposure to nanoparticles (NPs) has raise...
Pregnancy pathologies including gestational diabetes, intrauterine fetal growth restriction, and pre...
tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing ...
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays exte...
A challenge in modern drug therapy is to develop strategies for safer and more selective targeting o...
Quantification of fetal drug exposure remains challenging since sampling from the placenta or fetus ...
In this thesis we showed the implementation of complex biology in a large scale setting. The project...
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the leading cause...
ObjectiveStudying the biology of the human placenta represents a major experimental challenge. Altho...
The placenta is essential to the progression of a successful pregnancy. This specialized organ devel...
Decades ago the human placenta was thought to be an impenetrable barrier between mother and unborn c...
The placenta is essential to the progression of a successful pregnancy. This specialized organ devel...
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays exte...
With the commercialization of nanomaterials, environmental exposure to nanoparticles (NPs) has raise...
Pregnancy pathologies including gestational diabetes, intrauterine fetal growth restriction, and pre...
tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing ...
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays exte...
A challenge in modern drug therapy is to develop strategies for safer and more selective targeting o...