Radiological and chemical exposures and risks of cancer in the Constances cohort (COREXCA)

International audienceBackground - Populations are exposed to ionizing radiation (IR) and chemical pollutants (CPs) at various levels, via multiple natural and artificial sources, in the context of the residential environment, workplace and/or for medical reasons (diagnostic or therapeutic procedures). The carcinogenic effects of IR are well documented above dose levels of 100 milliGrays, but still less well below. In addition, the effects of joint exposures to IR and CPs on cancer risks are poorly documented.Objectives - The first objective of COREXCA is to carry out the broadest possible reconstruction of life-long doses of IR and several carcinogenic CPs (cadmium, nickel and chromium) from environmental sources (e.g. : natural radioactivity, nuclear installations and other artificial sources) and occupational activities, but also medical exposures, received by around 80,000 participants of the French Constances cohort https://www.constances.fr/).The second objective will be to estimate cancer risks associated with the cumulative doses of IR and CPs received by these participants