The Virulence of a Mouse-Adapted Semliki Forest Mechanism: a Model to Study the Pathogenesis

Vectors from the Semliki Forest virus (SFV) have been created to offer a simple method for expressing protein-encoding sequences in almost any animal cell. Acute encephalitis, subacute demyelinating meningoencephalomyelitis, and persistent subclinical central nervous system (CNS) infection are possible infection outcomes in mice, depending on age and viral strain. Infected mice under 12 days old exhibit severe symptoms of all viral types. While the A7 (74) strain is virulent, the L10 strain is equally pathogenic in mice older than 14 days