The DNA repair functional score variability of BRCA1 variants was evaluated by plotting the standard variance across four replicates (y-axis) against the mean functional score (x-axis). Variants with a standard deviation greater than 1 were removed from further analysis. (TIF)</p
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
<p>N: number; group 4: same DNA sample, different panels; group 5: same panel & tumor, different DNA...
The functional scores of 2172 variants (positions 1–302 of BRCA1) were color-coded based on the func...
The distribution of functional scores for each subpopulation of variants (missense, nonsense, synony...
A. Eighteen amino-terminal BRCA1 variants were tested in the singleton HDR assay for DNA repair func...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
Under the conditions of endogenous, wild-type BRCA1 (control siRNA, left) or of variant BRCA1 (BRCA1...
A. The number of variants in each pool of BRCA1 codons that were above the read count threshold and ...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
The functional scores from the current multiplexed HDR analysis (x-axis) were compared to the multip...
Purpose: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
PURPOSE: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
PURPOSE: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
<p>The melting profile of a wild type (WT) control is chosen as a horizontal base line and the relat...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
<p>N: number; group 4: same DNA sample, different panels; group 5: same panel & tumor, different DNA...
The functional scores of 2172 variants (positions 1–302 of BRCA1) were color-coded based on the func...
The distribution of functional scores for each subpopulation of variants (missense, nonsense, synony...
A. Eighteen amino-terminal BRCA1 variants were tested in the singleton HDR assay for DNA repair func...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
Under the conditions of endogenous, wild-type BRCA1 (control siRNA, left) or of variant BRCA1 (BRCA1...
A. The number of variants in each pool of BRCA1 codons that were above the read count threshold and ...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
The functional scores from the current multiplexed HDR analysis (x-axis) were compared to the multip...
Purpose: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
PURPOSE: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
PURPOSE: Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence vari...
<p>The melting profile of a wild type (WT) control is chosen as a horizontal base line and the relat...
Single nucleotide variants are the most frequent type of sequence changes detected in the genome and...
<p>N: number; group 4: same DNA sample, different panels; group 5: same panel & tumor, different DNA...
The functional scores of 2172 variants (positions 1–302 of BRCA1) were color-coded based on the func...