Supplementary Figure 2. Activity of BBT-176 in EGFR WT and EGFR exon 20 insertion models.</p
Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kin...
ABSTRACT Patients with non–small cell lung cancer (NSCLC) with activating EGF receptor ( EGFR) mutat...
Supplementary FIgures: The following supporting information can be downloaded. Figure S1: Structure ...
Supplementary Figure 4. Western blot of Ba/F3 cells with the EGFR 19Del/T790M/C797S mutation after B...
Supplementary Figure 3. Activity of osimertinib in EGFR 19Del-derived BBT-176-resistant clones. Abbr...
Supplementary Figure 10. Growth inhibition by BBT-176 with and without osimertinib in BBT-176-resist...
Supplementary Figure 1. Growth inhibition by BBT-176 with and without cetuximab in EGFR 19Del and EG...
Supplementary Figure 5. Growth inhibition by BBT-176 with and without cetuximab in BBT-176-resistant...
Supplementary Figure 6. Analysis of BBT-176 using in vivo models. A, Body weight changes in Ba/F3 EG...
Supplementary Figure 7. Duration of treatment and tumor response in all patients in QD dosing cohort...
Supplementary Figure 9. Circulating tumor DNA analysis data from Case 2. A, Allelic configuration of...
PURPOSE: Resistance to third-generation EGFR inhibitors including osimertinib arises in part from th...
Supplementary Figure 8. Circulating tumor DNA analysis data from Case 1. A, Allelic configuration an...
EGFR exon 20 insertions (Ex20Ins) account for 4% to 10% of EGFR activating mutations in non-small ce...
EGFR exon 20 alterations are rare events seen mainly in non-small cell lung cancer (NSCLC). They inc...
Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kin...
ABSTRACT Patients with non–small cell lung cancer (NSCLC) with activating EGF receptor ( EGFR) mutat...
Supplementary FIgures: The following supporting information can be downloaded. Figure S1: Structure ...
Supplementary Figure 4. Western blot of Ba/F3 cells with the EGFR 19Del/T790M/C797S mutation after B...
Supplementary Figure 3. Activity of osimertinib in EGFR 19Del-derived BBT-176-resistant clones. Abbr...
Supplementary Figure 10. Growth inhibition by BBT-176 with and without osimertinib in BBT-176-resist...
Supplementary Figure 1. Growth inhibition by BBT-176 with and without cetuximab in EGFR 19Del and EG...
Supplementary Figure 5. Growth inhibition by BBT-176 with and without cetuximab in BBT-176-resistant...
Supplementary Figure 6. Analysis of BBT-176 using in vivo models. A, Body weight changes in Ba/F3 EG...
Supplementary Figure 7. Duration of treatment and tumor response in all patients in QD dosing cohort...
Supplementary Figure 9. Circulating tumor DNA analysis data from Case 2. A, Allelic configuration of...
PURPOSE: Resistance to third-generation EGFR inhibitors including osimertinib arises in part from th...
Supplementary Figure 8. Circulating tumor DNA analysis data from Case 1. A, Allelic configuration an...
EGFR exon 20 insertions (Ex20Ins) account for 4% to 10% of EGFR activating mutations in non-small ce...
EGFR exon 20 alterations are rare events seen mainly in non-small cell lung cancer (NSCLC). They inc...
Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kin...
ABSTRACT Patients with non–small cell lung cancer (NSCLC) with activating EGF receptor ( EGFR) mutat...
Supplementary FIgures: The following supporting information can be downloaded. Figure S1: Structure ...